| First Author | Wickramasinghe SN | Year | 1994 |
| Journal | Alcohol Clin Exp Res | Volume | 18 |
| Issue | 6 | Pages | 1463-7 |
| PubMed ID | 7695045 | Mgi Jnum | J:22344 |
| Mgi Id | MGI:70222 | Doi | 10.1111/j.1530-0277.1994.tb01451.x |
| Citation | Wickramasinghe SN, et al. (1994) Macrophages are a major source of acetaldehyde in circulating acetaldehyde-albumin complexes formed after exposure of mice to ethanol. Alcohol Clin Exp Res 18(6):1463-7 |
| abstractText | C57BL mice were depleted of macrophages by an intravenous injection of liposome-encapsulated dichloromethylene diphosphonate (DCMDP), and control mice were uninjected or injected with empty liposomes. One day after injection, a proportion of the DCMDP-treated and control mice was continuously exposed to ethanol vapor for 4 days. Albumin fractions were separated from the sera of both ethanol-unexposed and ethanol-exposed animals and tested for cytotoxicity against a monolayer of A9 cells using two indicators of cytotoxicity: detachment of adherent cells and a decrease in the ability of cells to reduce tetrazolium. The results show that, in mice exposed to ethanol, macrophages are a major source of the acetaldehyde in circulating cytotoxic acetaldehyde-albumin complexes and presumably also of free acetaldehyde. |
