| Primary Identifier | MGI:5502770 | Allele Type | Targeted |
| Attribute String | Conditional ready, Humanized sequence, Inserted expressed sequence | Gene | Gt(ROSA)26Sor |
| Transmission | Germline | Strain of Origin | B6.Cg-Thy1<a> |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | The targeting contruct inserted into the locus contained a CAG promoter, floxed neomycin resistance and STOP cassette, and the human cDNA with a TCTG duplication at positions 956 to 959 in exon 12 (GenBank accession number NM_002520). This mutation is the most frequent mutation of the NPM1 gene in patients with acute myeloid leukemia (AML). |
