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Publication : Regulation of blood-testis barrier assembly in vivo by germ cells.

First Author  Li XY Year  2018
Journal  FASEB J Volume  32
Issue  3 Pages  1653-1664
PubMed ID  29183964 Mgi Jnum  J:270349
Mgi Id  MGI:6277702 Doi  10.1096/fj.201700681R
Citation  Li XY, et al. (2018) Regulation of blood-testis barrier assembly in vivo by germ cells. FASEB J 32(3):1653-1664
abstractText  The assembly of the blood-testis barrier (BTB) during postnatal development is crucial to support meiosis. However, the role of germ cells in BTB assembly remains unclear. Herein, Kit(W)/Kit(WV) mice were used as a study model. These mice were infertile, failing to establish a functional BTB to support meiosis due to c-Kit mutation. Transplantation of undifferentiated spermatogonia derived from normal mice into the testis of Kit(W)/Kit(WV) mice triggered functional BTB assembly, displaying cyclic remodeling during the epithelial cycle. Also, transplanted germ cells were capable of inducing Leydig cell testosterone production, which could enhance the expression of integral membrane protein claudin 3 in Sertoli cells. Early spermatocytes were shown to play a vital role in directing BTB assembly by expressing claudin 3, which likely created a transient adhesion structure to mediate BTB and cytoskeleton assembly in adjacent Sertoli cells. In summary, the positive modulation of germ cells on somatic cell function provides useful information regarding somatic-germ cell interactions.-Li, X.-Y., Zhang, Y., Wang, X.-X., Jin, C., Wang, Y.-Q., Sun, T.-C., Li, J., Tang, J.-X., Batool, A., Deng, S.-L., Chen, S.-R., Cheng, C. Y., Liu, Y.-X. Regulation of blood-testis barrier assembly in vivo by germ cells.
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