| Primary Identifier | IPR028924 | Type | Domain |
| Short Name | Perm-CXXC |
| description | This is a permuted version of a single unit of the zf-CXXC domain that is detected in the Demeter-like proteins and ROS1 (REPRESSOR OF SILENCING 1) from plants []. Demeter and ROS1 proteins catalyse the release of 5-methylcytosine (5-meC) from DNA by a glycosylase/lyase mechanism []. Structural comparisons show that the mono-CXXC is homologous to the structural-zinc binding domain of medium chain dehydrogenases []. The classical zf-CXXC domain binds nonmethyl-CpG dinucleotides. |
