| First Author | Tang T | Year | 2006 |
| Journal | J Pathol | Volume | 210 |
| Issue | 1 | Pages | 121-9 |
| PubMed ID | 16841371 | Mgi Jnum | J:112352 |
| Mgi Id | MGI:3656154 | Doi | 10.1002/path.2028 |
| Citation | Tang T, et al. (2006) Expression of the TAL1/SCL transcription factor in physiological and pathological vascular processes. J Pathol 210(1):121-9 |
| abstractText | The TAL1/SCL transcription factor is essential for haematopoietic commitment and vascular remodelling during embryonic development. To help clarify its role in postnatal vascular processes, we characterized the expression of mouse Tal1 protein by immunocytochemistry in several experimental models of blood vessel formation. In adult mice, Tal1 protein was expressed in rare microvascular endothelial cells and in extravascular cells provisionally identified as endothelial progenitors from their morphology, proximity to vessels and expression of vascular endothelial growth factor receptor-2. The number of Tal1-expressing endothelial cells increased significantly but transiently in all the models-hormone-induced ovulation, wound healing and tumour development. Finally, Tal1 protein was detected in the nuclei of newly formed lymphatic endothelial cells in tumour-bearing animals. These results show that TAL1 is expressed by vascular endothelial cells and endothelial progenitors at sites of physiological and pathological neovascularization and suggest a role for this transcription factor in adult vasculogenesis. This work also provides the first evidence for TAL1 expression in lymphangiogenesis. |
