| First Author | Lugus JJ | Year | 2009 |
| Journal | Blood | Volume | 113 |
| Issue | 3 | Pages | 563-6 |
| PubMed ID | 18957687 | Mgi Jnum | J:144056 |
| Mgi Id | MGI:3829835 | Doi | 10.1182/blood-2008-06-162750 |
| Citation | Lugus JJ, et al. (2009) Both primitive and definitive blood cells are derived from Flk-1+ mesoderm. Blood 113(3):563-6 |
| abstractText | Emerging evidence suggests that all hematopoietic and endothelial cells originate from Flk-1(+) mesoderm in the mouse. However, this concept has not been completely proven, especially for the origin of blood cells. Using either Flk1(+/Cre);Rosa26R-EYFP or Flk1(+/Cre);Rosa26R-LacZ mice, we permanently marked Flk-1(+) cells and their progenies to determine the relationship between hematopoietic tissues and cells that express Flk-1. In embryos, all blood cells within the yolk sac and aorta were of Flk-1(+) origin. In addition, nearly all CD45(+) cells in bone marrow and circulating blood in adults were of Flk-1(+) origin. These results provide clear evidence that all blood cells, primitive and definitive, in mice are derived from Flk-1(+) mesodermal cells. |
