| First Author | Voncken JW | Year | 1995 |
| Journal | Cell | Volume | 80 |
| Issue | 5 | Pages | 719-28 |
| PubMed ID | 7889565 | Mgi Jnum | J:23804 |
| Mgi Id | MGI:71493 | Doi | 10.1016/0092-8674(95)90350-x |
| Citation | Voncken JW, et al. (1995) Increased neutrophil respiratory burst in bcr-null mutants. Cell 80(5):719-28 |
| abstractText | Philadelphia (Ph)-positive leukemias invariably contain a chromosomal translocation fusing BCR to ABL. The BCR-ABL protein is responsible for leukemogenesis. Here we show that exposure of bcr-null mutant mice to gram-negative endotoxin led to severe septic shock and increased tissue injury by neutrophils. Neutrophils of bcr (-/-) mice showed a pronounced increase in reactive oxygen metabolite production upon activation and were more sensitive to priming stimuli. Activated (-/-) neutrophils displayed a 3-fold increased p21rac2 membrane translocation compared with (+/+) neutrophils. These results connect Bcr in vivo with the regulation of Rac-mediated superoxide production by the NADPH-oxidase system of leukocytes and suggest a link between Bcr function and the cell type affected in Ph-positive leukemia. |
