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Allele : Als2<tm1Dwc> alsin Rho guanine nucleotide exchange factor; targeted mutation 1, Don W Cleveland

Primary Identifier  MGI:6266856 Allele Type  Targeted
Attribute String  Null/knockout Gene  Als2
Transmission  Germline Strain of Origin  129S6/SvEvTac
Is Recombinase  false Is Wild Type  false
molecularNote  A PGK-neomycin selection cassette replaced most of exon 4 and a portion of intron 4, producing a translation product of 171 amino acids followed by 3 unique residues and a premature stop codon at amino acid 175. Immunoblot of brain lysates indicates no detectable full-length protein or short forms of the protein in homozygotes.
  • mutations:
  • Insertion,
  • Intragenic deletion
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

1 Carried By

0 Driven By

3 Publication categories