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Protein Coding Gene : Dennd1b DENN domain containing 1B
Primary Identifier  MGI:2447812 Organism  mouse, laboratory
Chromosome  1 NCBI Gene Number  329260
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0)

Enables guanyl-nucleotide exchange factor activity and small GTPase binding activity. Involved in T cell receptor signaling pathway; endocytic recycling; and positive regulation of T-helper 2 cell cytokine production. Predicted to be located in cytoplasmic vesicle. Predicted to be active in cytosol and nuclear speck. Orthologous to human DENND1B (DENN domain containing 1B).
PHENOTYPE: Homozygous KO results in enhanced allergic responses to aerosolized antigen challenges caused by delayed TCR down-modulation following receptor activation in T helper 2 cells. [provided by MGI curators]
  • synonyms:
  • MGI:2670998,
  • MGI:1924310,
  • F730008N07Rik,
  • DENN domain containing 1B,
  • RIKEN cDNA 4632404N19 gene,
  • 4930467M19Rik,
  • MGI:1922993,
  • 4632404N19Rik,
  • RIKEN cDNA F730008N07 gene,
  • Dennd1b,
  • RIKEN cDNA 6820401H01 gene,
  • cDNA sequence BC042698,
  • 6820401H01Rik,
  • RIKEN cDNA 4930467M19 gene,
  • MGI:2443969,
  • BC042698
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3 Involved In Mutations

Trail: ProteinCodingGene

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Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

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Features --> Overlapping features

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Function

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Homology

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Interactions

4 Pathways

Trail: ProteinCodingGene

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Gene --> Protein-Protein Interactions

Expression

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Phenotype

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