| First Author | Kondratiuk I | Year | 2013 |
| Journal | Behav Brain Res | Volume | 248 |
| Pages | 46-50 | PubMed ID | 23570858 |
| Mgi Jnum | J:197904 | Mgi Id | MGI:5494883 |
| Doi | 10.1016/j.bbr.2013.03.045 | Citation | Kondratiuk I, et al. (2013) Glycogen synthase kinase-3beta affects size of dentate gyrus and species-typical behavioral tasks in transgenic and knockout mice. Behav Brain Res 248:46-50 |
| abstractText | Glycogen synthase kinase-3 (GSK-3), a multifunctional serine-threonine kinase, is an important regulator in numerous signaling pathways and processes including adult brain neurogenesis. GSK-3 (mal)functioning was implicated in many diseases, in particular neurological and behavioral disorders. We investigated the impact of altered levels of the GSK-3beta isoform on hippocampal size, number of doublecortin-positive cells, and hippocampal-dependent behaviors. Both GSK-3beta transgenic mice (GSK-3beta[S9A] mice) and GSK-3beta neuron-specific knockout (GSK-3beta(n-/-)) mice, showed reduced size of the dentate gyrus (DG) and were impaired in three hippocampal-dependent, species-typical behavioral tasks: digging, marble burying and nest building. We further demonstrate that the number of differentiating, doublecortin-positive new neurons is reduced in GSK-3beta[S9A] mice, but not in GSK-3beta(n-/-) mice. We conclude that GSK-3beta activity must be critically controlled to allow wild type-like volume of the dentate gyrus and for normal execution of hippocampal-dependent, species-typical behavior. |
