Primary Identifier | MGI:98373 | Organism | mouse, laboratory |
Chromosome | 11 | NCBI Gene Number | 20692 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.3.0) Enables calcium ion binding activity and extracellular matrix binding activity. Acts upstream of or within several processes, including bone development; cellular response to growth factor stimulus; and pigmentation. Located in extracellular matrix and extracellular space. Is expressed in several structures, including brain; egg cylinder; genitourinary system; jaw; and sensory organ. Human ortholog(s) of this gene implicated in cervix carcinoma; endometrial carcinoma; multiple myeloma; and osteogenesis imperfecta type 17. Orthologous to human SPARC (secreted protein acidic and cysteine rich). PHENOTYPE: Homozygotes for targeted null mutations exhibit cataracts, reduced skin collagen content, accelerated wound closure, osteopenia associated with reduced bone remodeling, and increased growth of implanted tumors. [provided by MGI curators] |