| First Author | Boström KI | Year | 2016 |
| Journal | Atherosclerosis | Volume | 253 |
| Pages | 124-127 | PubMed ID | 27615595 |
| Mgi Jnum | J:325929 | Mgi Id | MGI:6878310 |
| Doi | 10.1016/j.atherosclerosis.2016.08.046 | Citation | Bostrom KI, et al. (2016) Endothelial-mesenchymal transition in atherosclerotic lesion calcification. Atherosclerosis 253:124-127 |
| abstractText | BACKGROUND AND AIMS: Endothelial-mesenchymal transitions (EndMTs) in endothelial cells (ECs) contribute to vascular disease. METHODS: We used ApoE(-/-) mice fed a high-fat/high-cholesterol diet. RESULTS: We reported evidence of EndMT in atherosclerotic lesions contributing to calcification. Stem cell and mesenchymal markers, including sex-determining region Y-box 2 (Sox2), were upregulated in aortic ECs of fat-fed ApoE(-/-) mice. Limiting Sox2 decreased marker expression and calcification in ApoE(-/-) aortas. Furthermore, a complex of serine proteases was upregulated in ApoE(-/-) aortic ECs. Blockade of these proteases reduced expression of Sox2 and atherosclerotic lesion calcification. CONCLUSIONS: Together, our data suggest that EndMTs contribute to atherosclerotic lesion calcification. |
