| First Author | Varnum DS | Year | 1974 |
| Journal | Mouse News Lett | Volume | 51 |
| Pages | 23-24 | Mgi Jnum | J:68948 |
| Mgi Id | MGI:1933738 | Citation | Varnum DS, et al. (1974) Malformed vertebra (Mv). Mouse News Lett 51:23-24 |
| abstractText | Full text of MNL contribution: 4. Malformed vertebra (Mv), a new semidominant mutation found in strain AKR/J in 1966 by Dr. Margaret Dickie, causes kinks at the tip of the tail and an occasional fused rib in heterozygotes. Homozygous fetuses can be identified at 12 days of gestation by stub tails and fusion of ribs. Homozygotes exhibit a severe disturbance of the whole axial skeleton. Most vertebrae show asymmetric fusions of neural arches in the cervical, thoracic, and lumbosacral region. The atlas is frequently unilaterally fused to the occiput. The ossification centra of the vertebral bodies are of varying size, and are not properly aligned. The thoracic basket is characterized by extensive fusions of ribs and their number is often reduced. Homozygous fetuses are still alive at 19 days of gestation, but die at birth or shortly thereafter. Tests for allelism with Hk and pu produced no short tailed or dead embryos. Linkage tests with fi, qk, W, Hm, and Spd were negative. (Varnum, Southard and Stevens) |
