| Primary Identifier | MGI:95710 | Organism | mouse, laboratory |
| Chromosome | 6 | NCBI Gene Number | 14602 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Enables growth hormone-releasing hormone receptor activity and peptide hormone binding activity. Involved in positive regulation of cell population proliferation. Acts upstream of or within several processes, including determination of adult lifespan; positive regulation of growth hormone secretion; and regulation of signal transduction. Located in plasma membrane. Is expressed in alimentary system; brain; metanephros; and spinal cord. Human ortholog(s) of this gene implicated in isolated growth hormone deficiency. Orthologous to human GHRHR (growth hormone releasing hormone receptor). PHENOTYPE: Homozygotes for a spontaneous null mutation exhibit reduced growth from 2 weeks of age, impaired growth hormone synthesis and release, obesity, decreased bone mass, reduced fertility in males, impaired first lactations, and extended life span. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
