| First Author | Paul A | Year | 2017 |
| Journal | Science | Volume | 356 |
| Issue | 6345 | Pages | 1383-1386 |
| PubMed ID | 28619719 | Mgi Jnum | J:244644 |
| Mgi Id | MGI:5913423 | Doi | 10.1126/science.aal3839 |
| Citation | Paul A, et al. (2017) Hypothalamic regulation of regionally distinct adult neural stem cells and neurogenesis. Science 356(6345):1383-1386 |
| abstractText | Neural stem cells (NSCs) in specialized niches in the adult mammalian brain generate neurons throughout life. NSCs in the adult mouse ventricular-subventricular zone (V-SVZ) exhibit a regional identity and, depending on their location, generate distinct olfactory bulb interneuron subtypes. Here, we show that the hypothalamus, a brain area regulating physiological states, provides long-range regionalized input to the V-SVZ niche and can regulate specific NSC subpopulations. Hypothalamic proopiomelanocortin neurons selectively innervate the anterior ventral V-SVZ and promote the proliferation of Nkx2.1+ NSCs and the generation of deep granule neurons. Accordingly, hunger and satiety regulate adult neurogenesis by modulating the activity of this hypothalamic-V-SVZ connection. Our findings reveal that neural circuitry, via mosaic innervation of the V-SVZ, can recruit distinct NSC pools, allowing on-demand neurogenesis in response to physiology and environmental signals. |
