| First Author | Tervonen T | Year | 2005 |
| Journal | Brain Res Mol Brain Res | Volume | 133 |
| Issue | 1 | Pages | 162-5 |
| PubMed ID | 15661377 | Mgi Jnum | J:95566 |
| Mgi Id | MGI:3526514 | Doi | 10.1016/j.molbrainres.2004.09.023 |
| Citation | Tervonen T, et al. (2005) Rgs4 mRNA expression is decreased in the brain of Fmr1 knockout mouse. Brain Res Mol Brain Res 133(1):162-5 |
| abstractText | In the Fmr1 knockout mice, a model for fragile X mental retardation syndrome, the levels of regulator of G-protein signaling (Rgs) 4 but not Rgs2 mRNA were considerably reduced (65% from control) in the cerebral cortex and hippocampal CA1 region. The expression of Rgs4 was normal in animals lacking a related protein, FXR2P, indicating that the decrease in Rgs4 expression was specific for the absence of FMRP, and suggests a role for FMRP in G-protein signaling. |
