| First Author | Müllner FE | Year | 2024 |
| Journal | Neuron | PubMed ID | 38917805 |
| Mgi Jnum | J:351463 | Mgi Id | MGI:7703046 |
| Doi | 10.1016/j.neuron.2024.06.001 | Citation | Mullner FE, et al. (2024) Individual thalamic inhibitory interneurons are functionally specialized toward distinct visual features. Neuron |
| abstractText | Inhibitory interneurons in the dorsolateral geniculate nucleus (dLGN) are situated at the first central synapse of the image-forming visual pathway, but little is known about their function. Given their anatomy, they are expected to be multiplexors, integrating many different retinal channels along their dendrites. Here, using targeted single-cell-initiated rabies tracing, we found that mouse dLGN interneurons exhibit a degree of retinal input specialization similar to thalamocortical neurons. Some are anatomically highly specialized, for example, toward motion-selective information. Two-photon calcium imaging performed in vivo revealed that interneurons are also functionally specialized. In mice lacking retinal horizontal direction selectivity, horizontal direction selectivity is reduced in interneurons, suggesting a causal link between input and functional specialization. Functional specialization is not only present at interneuron somata but also extends into their dendrites. Altogether, inhibitory interneurons globally display distinct visual features which reflect their retinal input specialization and are ideally suited to perform feature-selective inhibition. |
