| First Author | Kaplan MH | Year | 2011 |
| Journal | Blood | Volume | 117 |
| Issue | 23 | Pages | 6198-201 |
| PubMed ID | 21505191 | Mgi Jnum | J:174700 |
| Mgi Id | MGI:5140643 | Doi | 10.1182/blood-2011-02-334367 |
| Citation | Kaplan MH, et al. (2011) STAT3-dependent IL-21 production from T helper cells regulates hematopoietic progenitor cell homeostasis. Blood 117(23):6198-201 |
| abstractText | The contribution of specific cell types to the production of cytokines that regulate hematopoiesis is still not well defined. We have previously identified T cell-dependent regulation of hematopoietic progenitor cell (HPC) numbers and cycling. In this report, we demonstrated that HPC activity is decreased in mice with STAT3-deficient T cells, a phenotype that is not because of decreased expression of IL-17 or RORgammat. STAT3 expression in T cells was required for IL-21 production by multiple T helper subsets, and neutralization of IL-21 resulted in decreased HPC activity identical to that in mice with STAT3-deficient T cells. Importantly, injection of IL-21 rescued HPC activity in mice with STAT3-deficient T cells. Thus, STAT3-dependent IL-21 production in T cells is required for HPC homeostasis. |
