Primary Identifier | MGI:1913189 | Allele Type | Targeted |
Gene | Notch1 | Transmission | Germline |
Strain of Origin | 129X1/SvJ | Is Recombinase | false |
Is Wild Type | false |
molecularNote | Introduction of a point mutation in codon 1744 converting GTG (valine) to GGG (glycine) in exon F. This mutation is predicted to eliminate proteolytic processing of Notch1. There is also a 42 bp pLox site insertion in the intron between exons E and F. |