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Allele : Tg(Myh6-Pik3r1/PIK3CA)BSiz transgene insertion B, Seigo Izumo
Primary Identifier  MGI:3619920 Allele Type  Transgenic
Attribute String  Constitutively active, Inserted expressed sequence Gene  Tg(Myh6-Pik3r1/PIK3CA)BSiz
Strain of Origin  FVB/N Is Recombinase  false
Is Wild Type  false
molecularNote  This transgene consists of the mouse alpha myosin heavy chain (Myh6) promoter and the inter-Src homology 2 (iSH2) domain of Pik3r1 (p85) fused to the N-terminus of bovine PIK3CA (p110alpha). Myh6 drives the expression of a constitutively active phosphatidylinositol 3-kinase specifically in cardiac myocytes. Immunoprecipitation and western blotting confirmed transgene expression exclusively in the heart and a lipid kinase assay indicated that phosphatidylinositol 3-kinase activity was increased 6.5-fold.
  • mutations:
  • Insertion
  • synonyms:
  • caPI3K,
  • caPI3Kalpha,
  • caPI3Kalpha,
  • caPI3K
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

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Trail: Allele




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