| First Author | Peng B | Year | 1998 |
| Journal | Leuk Res | Volume | 22 |
| Issue | 6 | Pages | 509-16 |
| PubMed ID | 9678717 | Mgi Jnum | J:50245 |
| Mgi Id | MGI:1290101 | Doi | 10.1016/s0145-2126(98)00021-6 |
| Citation | Peng B, et al. (1998) The correlation of telomerase and IL-10 with leukemia transformation in a mouse model of chronic lymphocytic leukemia (CLL). Leuk Res 22(6):509-16 |
| abstractText | Telomerase activity is upregulated in activated and malignant lymphocytes. We studied the correlation of telomerase and IL-10 to leukemia transformation in the NZB mouse model of human chronic lymphocytic leukemia (CLL). Telomerase levels increased from early to late leukemic stages, likewise IL-10 gene expression levels increased with the leukemic progression. The inverse relation-ship of telomerase and IL-10 levels to the survival of NZB mice was also established. Our data suggested that telomerase and IL-10 were involved in transformation in the murine model of CLL and the detection of telomerase activities might be of value in the prediction of CLL progression. |
