| First Author | Bollag RJ | Year | 1994 |
| Journal | Nat Genet | Volume | 7 |
| Issue | 3 | Pages | 383-9 |
| PubMed ID | 7920656 | Mgi Jnum | J:18978 |
| Mgi Id | MGI:67209 | Doi | 10.1038/ng0794-383 |
| Citation | Bollag RJ, et al. (1994) An ancient family of embryonically expressed mouse genes sharing a conserved protein motif with the T locus. Nat Genet 7(3):383-9 |
| abstractText | The T locus encodes a product with DNA binding activity that is likely to play a role in the development of all vertebrate organisms. We have identified and characterized a novel family of mouse genes that share a protein motif, the T-box, with the prototypical T locus. The T-box domain of the T locus co-localizes with its DNA binding activity. Each T-box gene is expressed in a unique temporal and spatial pattern during embryogenesis. Phylogenetic analysis suggests that at least three T-box genes were present in the common ancestor to vertebrates and invertebrates. Thus, members of the T-box family could have played a role in the evolution of all metazoan organisms. |
