| First Author | Yamasaki S | Year | 2008 |
| Journal | Int Immunol | Volume | 20 |
| Issue | 10 | Pages | 1289-97 |
| PubMed ID | 18664516 | Mgi Jnum | J:140219 |
| Mgi Id | MGI:3812285 | Doi | 10.1093/intimm/dxn085 |
| Citation | Yamasaki S, et al. (2008) Selective impairment of FcepsilonRI-mediated allergic reaction in Gads-deficient mice. Int Immunol 20(10):1289-97 |
| abstractText | Gads is a Grb2-like adaptor protein expressed in hematopoietic cells. We demonstrated that mast cells from Gads(-/-) mice have selective functional defects. Bone marrow-derived mast cells from Gads(-/-) mice failed to induce Ca(2+) mobilization, degranulation and cytokine production upon cross-linking of FcepsilonRI. In vivo passive cutaneous anaphylaxis was also greatly impaired in Gads(-/-) mice. In contrast, Gads was dispensable for Toll-like receptor-mediated cytokine production in mast cells. Accordingly, mast cell-dependent resistance to acute peritoneal bacterial infection is not reduced in Gads(-/-) mice in vivo. Moreover, mature T and B cell responses and antibody production upon immunization were apparently normal in Gads(-/-) mice. Thus, inhibition of Gads in vivo would suppress the IgE-mediated allergic reaction with minimum adverse effects on both innate and acquired immune responses, and Gads could be an ideal target for the control of allergic responses. |
