| Primary Identifier | IPR037959 | Type | Domain |
| Short Name | PICK1_BAR |
| description | Protein Interacting with C Kinase 1 (PICK1) is highly expressed in brain and testes. It plays a key role in the trafficking of AMPA receptors, which are critical for regulating synaptic strength and may be important in cellular processes involved in learning and memory [, ]. PICK1 is also critical in the early stages of spermiogenesis. Mice deficient in PICK1 are infertile and show characteristics of the human disease globozoospermia such as round-headed sperm, reduced sperm count, and severely impaired sperm motility []. PICK1 may also be involved in the neuropathogenesis of schizophrenia [].PICK1 contains an N-terminal PDZ domain and a C-terminal BAR domain [], also designated as AH (arfaptin homology) domain []. BAR domains form dimers that bind to membranes, induce membrane bending and curvature, and may also be involved in protein-protein interactions. The BAR domain of PICK1 is necessary for its membrane localization and activation [, ]. |
