| First Author | Ahrens R | Year | 2012 |
| Journal | Am J Pathol | Volume | 180 |
| Issue | 4 | Pages | 1535-46 |
| PubMed ID | 22322300 | Mgi Jnum | J:182002 |
| Mgi Id | MGI:5314564 | Doi | 10.1016/j.ajpath.2011.12.036 |
| Citation | Ahrens R, et al. (2012) Intestinal mast cell levels control severity of oral antigen-induced anaphylaxis in mice. Am J Pathol 180(4):1535-46 |
| abstractText | Food-triggered anaphylaxis can encompass a variety of symptoms that affect multiple organ systems and can be life threatening. The molecular distinction between non-life-threatening and life-threatening modes of such anaphylaxis has not yet been delineated. In this study, we sought to identify the specific immune functions that regulate the severity of oral antigen-induced anaphylaxis. We thus developed an experimental mouse model in which repeated oral challenge of ovalbumin-primed mice induced an FcepsilonRI- and IgE-dependent oral antigen-triggered anaphylaxis that involved multiple organ systems. Strikingly, the severity of the systemic symptoms of anaphylaxis (eg, hypothermia) positively correlated with the levels of intestinal mast cells (r = -0.53; P < 0.009). In addition, transgenic mice with both increased intestinal and normal systemic levels of mast cells showed increased severity of both intestinal and extra-intestinal symptoms of IgE-mediated passive as well as oral antigen- and IgE-triggered anaphylaxis. In conclusion, these observations indicate that the density of intestinal mast cells controls the severity of oral antigen-induced anaphylaxis. Thus, an awareness of intestinal mast cell levels in patients with food allergies may aid in determining their susceptibility to life-threatening anaphylaxis and may eventually aid in the treatment of food-triggered anaphylaxis. |
