| First Author | Washburn LL | Year | 1989 |
| Journal | Genetics | Volume | 123 |
| Issue | 1 | Pages | 173-9 |
| PubMed ID | 2806881 | Mgi Jnum | J:10075 |
| Mgi Id | MGI:58532 | Doi | 10.1093/genetics/123.1.173 |
| Citation | Washburn LL, et al. (1989) Normal testis determination in the mouse depends on genetic interaction of a locus on chromosome 17 and the Y chromosome. Genetics 123(1):173-9 |
| abstractText | We previously described a locus on chromosome (Chr) 17 of the mouse that is critical for normal testis development. This locus was designated T-associated sex reversal (Tas) because it segregated with the dominant brachyury allele hairpin tail (Thp) and caused gonads of C57BL/6J XY, Thp/+ individuals to develop as ovaries or ovotestes rather than as testes. To clarify the inheritance of Tas, we investigated the effects of T-Orleans (TOrl), another brachyury mutation, on gonad development. We found that gonads of C57BL/6J XY, Thp/+ and TOrl/+ mice develop ovarian tissue if the Y chromosome is derived from the AKR/J inbred strain, whereas normal testicular development occurs in the presence of a Y chromosome derived from the C57BL/6J inbred strain. From these observations we conclude that: (1) Tas is located in a region on Chr 17 common to the deletions associated with Thp, and TOrl, and (2) the Y-linked testis determining gene, Tdy, carried by the AKR/J inbred strain differs from that of the C57BL/6J inbred strain. We suggest that in mammals Tdy is not the sole testis determinant because autosomal loci must be genetically compatible with Tdy for normal testicular development. |
