| First Author | Dai G | Year | 1998 |
| Journal | Endocrinology | Volume | 139 |
| Issue | 12 | Pages | 5157-63 |
| PubMed ID | 9832456 | Mgi Jnum | J:46755 |
| Mgi Id | MGI:1271054 | Doi | 10.1210/endo.139.12.6391 |
| Citation | Dai GL, et al. (1998) A new member of the mouse prolactin (PRL)-like protein-C subfamily, PRL-like protein-C alpha: Structure and expression. Endocrinology 139(12):5157-5163 |
| abstractText | In this study, we establish the presence of a unique member of the PRL-like protein-C (PLP-C) subfamily in the mouse, PLP-C alpha, characterize its complementary DNA and gene, and map its chromosomal location and pattern of expression during pregnancy. Mouse PLP-C alpha encodes for a 239 amino acid protein and possesses from 69-71% identity with rat PLP-C, PLP-CV, PLP-D, and PLP-H. Another feature characteristic of PLP-C subfamily members that is also present in mouse PLP-C alpha is a 6-exon/5-intron gene structure including an aromatic domain encoded by exon 3. Southern analysis with mouse and rat PLP-C subfamily probes suggested the existence of a single mouse PLP-C alpha gene. Mouse PLP-C alpha maps to chromosome 13 along with other members of the mouse PRL family. Expression of mouse PLP-C alpha increases dramatically as gestation advances and is restricted to spongiotrophoblast and trophoblast giant cells of the junctional zone. In summary, we have established the presence of a new PLP-C subfamily member in the mouse and demonstrated its similarity in structure and expression to rat PLP-C subfamily members. This level of conservation between species expands the biological significance of the PLP-C subfamily and provides additional opportunities for genetically evaluating its function. |
