| First Author | Miwa H | Year | 2009 |
| Journal | FEBS Lett | Volume | 583 |
| Issue | 22 | Pages | 3643-8 |
| PubMed ID | 19852960 | Mgi Jnum | J:154664 |
| Mgi Id | MGI:4397715 | Doi | 10.1016/j.febslet.2009.10.044 |
| Citation | Miwa H, et al. (2009) A novel neural-specific BMP antagonist, Brorin-like, of the Chordin family. FEBS Lett 583(22):3643-8 |
| abstractText | We identified a gene encoding a novel secreted protein in mice, humans, and zebrafish. As the protein of 222 amino acids is similar to Brorin, a secreted BMP antagonist, which is a member of the Chordin family, we named it Brorin-like. Recombinant Brorin-like protein weakly but significantly inhibited the activity of BMP in mouse preosteoblastic cells and promoted neurogenesis in mouse neural precursor cells. Brorin-like was predominantly expressed in the adult brain and embryonic neural tissues. The inhibition of Brorin-like functions in zebrafish resulted in the impairment of neural development. Brorin-like potentially plays roles in neural development and functions. |
