| First Author | Antica M | Year | 1997 |
| Journal | Immunol Lett | Volume | 55 |
| Issue | 1 | Pages | 47-51 |
| PubMed ID | 9093881 | Mgi Jnum | J:39724 |
| Mgi Id | MGI:87076 | Doi | 10.1016/s0165-2478(96)02682-x |
| Citation | Antica M, et al. (1997) Stem cell antigen 2 expression in adult and developing mice. Immunol Lett 55(1):47-51 |
| abstractText | Stem cell antigen 2 (Sca-2) expression can distinguish the most immature T-lymphocyte precursors in the thymus from the hemopoietic stem cells. Sequence analysis of the Sca-2 protein showed that Sca-2 is a glycosylphosphatidylinositol (GPI) anchored molecule that shares some characteristics with the members of the Ly-6 multigene family, and that it is the same as the thymic shared antigen-1 (TSA-1). Here we extend these studies and critically reassess the expression of the Sca-2/TSA-1 antigen in hematopoietic tissues of adult and developing mice. With more sensitive methods we show that the distribution of Sca-2/TSA-1 differs from existing reports. We find especially high expression of Sca-2/TSA1 at day 14 of fetal development. |
