| First Author | Xiafukaiti G | Year | 2019 |
| Journal | Mol Cell Biol | Volume | 39 |
| Issue | 17 | PubMed ID | 31208980 |
| Mgi Jnum | J:289313 | Mgi Id | MGI:6434985 |
| Doi | 10.1128/MCB.00080-19 | Citation | Xiafukaiti G, et al. (2019) MafB Is Important for Pancreatic beta-Cell Maintenance under a MafA-Deficient Condition. Mol Cell Biol 39(17) |
| abstractText | The pancreatic-islet-enriched transcription factors MafA and MafB have unique expression patterns in beta cells in rodents. MafA is specifically expressed in beta cells and is a key regulatory factor for maintaining adult beta-cell function, whereas MafB plays an essential role in beta-cell development during embryogenesis, and its expression in beta cells gradually decreases and is restricted to alpha cells after birth in rodents. However, it was previously observed that MafB started to be reexpressed in insulin-positive (insulin(+)) beta cells in MafA-deficient adult mice. To elucidate how MafB functions in the adult beta cell under MafA-deficient conditions, we generated MafA and MafB double-knockout (A0B0) mice in which MafB was specifically deleted from beta cells. As a result, the A0B0 mice became more vulnerable to diabetes under a high-fat diet (HFD) treatment, with impaired islet formation and a decreased number of insulin(+) beta cells because of increased beta-cell apoptosis, indicating MafB can take part in the maintenance of adult beta cells under certain pathological conditions. |
