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Publication : Regulation of marginal zone B cell development by MINT, a suppressor of Notch/RBP-J signaling pathway.

First Author  Kuroda K Year  2003
Journal  Immunity Volume  18
Issue  2 Pages  301-12
PubMed ID  12594956 Mgi Jnum  J:82332
Mgi Id  MGI:2652300 Doi  10.1016/s1074-7613(03)00029-3
Citation  Kuroda K, et al. (2003) Regulation of marginal zone B cell development by MINT, a suppressor of Notch/RBP-J signaling pathway. Immunity 18(2):301-12
abstractText  We found that Msx2-interacting nuclear target protein (MINT) competed with the intracellular region of Notch for binding to a DNA binding protein RBP-J and suppressed the transactivation activity of Notch signaling. Although MINT null mutant mice were embryonic lethal, MINT-deficient splenic B cells differentiated about three times more efficiently into marginal zone B cells with a concomitant reduction of follicular B cells. MINT is expressed in a cell-specific manner: high in follicular B cells and low in marginal zone B cells. Since Notch signaling directs differentiation of marginal zone B lymphocytes and suppresses that of follicular B lymphocytes in mouse spleen, the results indicate that high levels of MINT negatively regulate Notch signaling and block differentiation of precursor B cells into marginal zone B cells. MINT may serve as a functional homolog of Drosophila Hairless.
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