| First Author | McCary LC | Year | 1999 |
| Journal | Arch Biochem Biophys | Volume | 368 |
| Issue | 2 | Pages | 249-56 |
| PubMed ID | 10441375 | Mgi Jnum | J:56835 |
| Mgi Id | MGI:1342789 | Doi | 10.1006/abbi.1999.1286 |
| Citation | McCary LC, et al. (1999) A characterization of vitamin D-independent intestinal calcium absorption in the osteopetrotic (op/op) mouse. Arch Biochem Biophys 368(2):249-56 |
| abstractText | Previous work in our laboratory showed that the osteopetrotic (op/op) mouse possesses a vitamin D-independent mechanism of intestinal calcium absorption. This study was performed in an effort to further characterize the mechanism. The vitamin D-deficient op/op mouse absorbed calcium faster than either a vitamin D-deficient or 1, 25-dihydroxyvitamin D(3)-supplemented wild-type mouse. This increased rate of absorption was not found at concentrations of calcium that result in diffusional calcium absorption. Thus, vitamin D-deficient op/op mice had intestinal calcium absorption similar to that of vitamin D-deficient wild-type littermates when increasing levels of calcium were administered. Also, mRNA and protein levels of calbindin-D9k were similar in vitamin D-deficient wild-type and op/op mice as well as in wild-type and op/op mice treated with 1, 25-dihydroxyvitamin D(3). Therefore, the mechanism of vitamin D-independent intestinal calcium absorption in the op/op mouse is distinct from vitamin D-dependent intestinal calcium absorption. Copyright 1999 Academic Press. |
