| First Author | Weinstein IB | Year | 2008 |
| Journal | Cancer Res | Volume | 68 |
| Issue | 9 | Pages | 3077-80; discussion 3080 |
| PubMed ID | 18451130 | Mgi Jnum | J:134632 |
| Mgi Id | MGI:3789430 | Doi | 10.1158/0008-5472.CAN-07-3293 |
| Citation | Weinstein IB, et al. (2008) Oncogene addiction. Cancer Res 68(9):3077-80; discussion 3080 |
| abstractText | Cancer cells contain multiple genetic and epigenetic abnormalities. Despite this complexity, their growth and survival can often be impaired by the inactivation of a single oncogene. This phenomenon, called 'oncogene addiction,' provides a rationale for molecular targeted therapy. The efficacy of this strategy requires novel methods, including integrative genomics and systems biology, to identify the state of oncogene addiction (i.e., the 'Achilles heel') in specific cancers. Combination therapy may also be required to prevent the escape of cancers from a given state of oncogene addiction. |
