Primary Identifier | MGI:1923800 | Organism | mouse, laboratory |
Chromosome | 12 | NCBI Gene Number | 52504 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.3.0) Predicted to be involved in centromere complex assembly. Predicted to be located in nuclear body. Predicted to be part of Mis6-Sim4 complex. Is expressed in several structures, including central nervous system; genitourinary system; jaw; sensory organ; and thymus primordium. Orthologous to human CENPO (centromere protein O). PHENOTYPE: Mice homozygous for a knock-out allele exhibit decreased embryo size, a rudimentary egg cylinder, failure of primitive streak formation, absent primitive node and head folds, failure to gastrulate, and complete lethality prior to organogenesis. [provided by MGI curators] |