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Protein Coding Gene : Smc5 structural maintenance of chromosomes 5
Primary Identifier  MGI:2385088 Organism  mouse, laboratory
Chromosome  19 NCBI Gene Number  226026
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0)

Predicted to enable DNA secondary structure binding activity and single-stranded DNA binding activity. Acts upstream of or within several processes, including chromosome condensation; mitotic cell cycle phase transition; and protein localization to chromosome, centromeric region. Located in PML body; chromosome; and cytoplasm. Part of Smc5-Smc6 complex. Is expressed in ovary; secondary spermatocyte; and testis. Human ortholog(s) of this gene implicated in mosaic variegated aneuploidy syndrome. Orthologous to human SMC5 (structural maintenance of chromosomes 5).
PHENOTYPE: Homozygous knockout in embryonic stem cells causes abnormal mitosis, increased apoptosis and a shift from pluripotency to differentiation. [provided by MGI curators]
  • synonyms:
  • SMC5 structural maintenance of chromosomes 5-like 1 (yeast),
  • structural maintenance of chromosomes 5,
  • Smc5l1,
  • Smc5,
  • MGC:7569
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