| First Author | Gavazzi G | Year | 2006 |
| Journal | FEBS Lett | Volume | 580 |
| Issue | 2 | Pages | 497-504 |
| PubMed ID | 16386251 | Mgi Jnum | J:105425 |
| Mgi Id | MGI:3615064 | Doi | 10.1016/j.febslet.2005.12.049 |
| Citation | Gavazzi G, et al. (2006) Decreased blood pressure in NOX1-deficient mice. FEBS Lett 580(2):497-504 |
| abstractText | To understand the role of the superoxide-generating NADPH oxidase NOX1 in the vascular system, we have generated NOX1-deficient mice. NOX1-deficient mice had a moderately decreased basal blood pressure. In response to angiotensin II they showed an almost complete loss of the sustained blood pressure response, while the initial increase was conserved. NOX1-deficient mice showed a marked reduction in aortic media hypertrophy. Angiotensin II-induced smooth muscle cell proliferation was conserved, but there was a marked decrease in extracellular matrix accumulation. Our results establish a role for NOX1 in blood pressure regulation and vascular angiotensin II response. |
