| First Author | Kuwano K | Year | 1999 |
| Journal | J Clin Invest | Volume | 104 |
| Issue | 1 | Pages | 13-9 |
| PubMed ID | 10393694 | Mgi Jnum | J:115307 |
| Mgi Id | MGI:3691371 | Doi | 10.1172/JCI5628 |
| Citation | Kuwano K, et al. (1999) Essential roles of the Fas-Fas ligand pathway in the development of pulmonary fibrosis. J Clin Invest 104(1):13-9 |
| abstractText | The Fas ligand is predominantly expressed in activated T lymphocytes and is one of the major effector molecules of cytotoxic T lymphocytes and natural killer cells. Previously, we found excessive apoptosis of epithelial cells and infiltrating lymphocytes expressing Fas ligand mRNA in the lung tissue of bleomycin-induced pulmonary fibrosis in mice. Here we demonstrated that the administration of a soluble form of Fas antigen or anti-Fas ligand antibody prevented the development of this model and that lpr and gld mice were resistant against the induction of pneumopathy. These results suggest that the Fas-Fas ligand pathway plays an essential role in the development of pulmonary fibrosis and that preventing this pathway could have therapeutic value in lung injury and fibrosis. |
