| First Author | Metcalf D | Year | 1985 |
| Journal | Science | Volume | 229 |
| Issue | 4708 | Pages | 16-22 |
| PubMed ID | 2990035 | Mgi Jnum | J:11999 |
| Mgi Id | MGI:60262 | Doi | 10.1126/science.2990035 |
| Citation | Metcalf D (1985) The granulocyte-macrophage colony-stimulating factors. Science 229(4708):16-22 |
| abstractText | The granulocyte-macrophage colony-stimulating factors are well-characterized specific glycoproteins that interact to control the production, differentiation, and function of two related white cell populations of the blood, the granulocytes and monocyte-macrophages. Widely produced in the body, these regulators probably play an important role in resistance to infections. The proliferation of myeloid leukemia cells remains dependent on stimulation by colony-stimulating factors, although one of them also has the ability to suppress leukemic populations by inducing terminal differentiation. |
