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Publication : Muscle development in mdx mutant mice.

First Author  Dangain J Year  1984
Journal  Muscle Nerve Volume  7
Issue  9 Pages  700-4
PubMed ID  6543918 Mgi Jnum  J:8039
Mgi Id  MGI:56508 Doi  10.1002/mus.880070903
Citation  Dangain J, et al. (1984) Muscle development in mdx mutant mice. Muscle Nerve 7(9):700-4
abstractText  Mechanical and contractile properties of tibialis anterior (TA) muscles from X-linked muscular dystrophic (mdx) mutant mice at different stages of development are compared to those of muscles from normal control animals. There is no difference between the tension output, speeds of contraction and relaxation, and weight of TA muscles from mutant adults and normal control animals. However, it is found that in 3-4-week-old mutant animals, tension output and muscle weight are very much reduced, and half relaxation time is prolonged. Thus, during this stage of development, muscles from mdx mice do not function properly. Histological examination of these muscles provides further evidence that, in these animals, rapid muscle destruction occurs at a particular time of development and that it is followed by complete recovery. This new mutant therefore presents an interesting case of muscle destruction and rapid regeneration. However, it is not an adequate model for Duchenne muscular dystrophy.
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