Primary Identifier | MGI:3056727 | Allele Type | Transgenic |
Attribute String | Inserted expressed sequence | Gene | Tg(Tcrb)93Vbo |
Strain of Origin | (CBA/BrA x C57BL/LiA)F2 | Is Recombinase | false |
Is Wild Type | false |
description | In transgenic mice, T lymphocytes express the transgene on cell surfaces while the protein products encoded by endogenous Tcrb genes are not expressed. Most homozygous transgenic mice do not survive beyond postnatal week four. |
molecularNote | The transgene contains a rearranged genomic segment derived from the Tcrb locus, and was constructed from B6 (Tcrb-V8.2,Tcrb-D) and BALB/c (Tcrb-J, Tcrb-C) sequences. Over 98% of T cells express the transgenic TCR-beta chain in hemizygous mice. The rearranged beta-chain sequence was isolated from an anti-H-Y, H-2Db-restricted CD8+ T cell clone, B6.2.16. |