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Protein Coding Gene : Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide

Primary Identifier  MGI:109484 Organism  mouse, laboratory
Chromosome  15 NCBI Gene Number  22631
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.3.0)

Enables protein domain specific binding activity. Involved in several processes, including negative regulation of transcription by RNA polymerase II; synaptic target recognition; and tube morphogenesis. Acts upstream of or within ERK1 and ERK2 cascade; protein targeting; and regulation of programmed cell death. Located in nucleus. Is active in hippocampal mossy fiber to CA3 synapse. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and hemolymphoid system gland. Used to study schizophrenia. Orthologous to human YWHAZ (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta).
PHENOTYPE: Mice homozygous for a knock-out allele exhibit growth retardation after P14, some postnatal lethality by P21. Mice homozygous for one gene trap allele also exhibit neurodevelopmental and neuropsychiatric behaviour defects. [provided by MGI curators]
  • synonyms:
  • expressed sequence AU020854,
  • 1110013I11Rik,
  • MGI:2146042,
  • MGI:2146113,
  • RIKEN cDNA 1110013I11 gene,
  • MGI:2146160,
  • AU020854,
  • AL022924,
  • expressed sequence AI596267,
  • tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide,
  • 14-3-3 zeta,
  • MGI:1915893,
  • AI596267,
  • MGD-MRK-39483,
  • Ywhaz,
  • expressed sequence AL022924

Features --> Cross References

Genome

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0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

2 Involved In Mutations

0 Strain

0 Transcripts

1 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

40 Pathways

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications

 

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0 Driver For