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Allele : Lepr<db> leptin receptor; diabetes

Primary Identifier  MGI:1856009 Allele Type  Spontaneous
Gene  Lepr Inheritance Mode  Recessive
Strain of Origin  C57BLKS/J Is Recombinase  false
Is Wild Type  false
description 

Phenotypic Similarity to Human Syndrome: Gestational Diabetes J:219658

molecularNote  An intronic G-to-T transversion in this allele created a donor splice site that causes abnormal splicing and the inclusion of 106 nt of intronic sequence in the transcript, leading to premature termination of the long cellular domain of the Ob-Rb splice form and loss of its signal transducing function.
  • mutations:
  • Single point mutation
  • synonyms:
  • leprdb,
  • leprdb,
  • Lepr-,
  • db,
  • Lep<db>,
  • db/db,
  • db/db,
  • Lepr<db-1J>,
  • Lepr-,
  • Lepr<db-1J>,
  • Lep<db>,
  • db
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

39 Carried By

0 Driven By

1987 Publication categories