Primary Identifier | MGI:1856009 | Allele Type | Spontaneous |
Gene | Lepr | Inheritance Mode | Recessive |
Strain of Origin | C57BLKS/J | Is Recombinase | false |
Is Wild Type | false |
description | Phenotypic Similarity to Human Syndrome: Gestational Diabetes J:219658 |
molecularNote | An intronic G-to-T transversion in this allele created a donor splice site that causes abnormal splicing and the inclusion of 106 nt of intronic sequence in the transcript, leading to premature termination of the long cellular domain of the Ob-Rb splice form and loss of its signal transducing function. |