| Primary Identifier | IPR013719 | Type | Domain |
| Short Name | RTT106/SPT16-like_middle_dom |
| description | This entry represents a domain found in the middle region of several eukaryotic proteins [, ]. It is present in various FACT (facilitates chromatin transactions) complex subunits, such as Spt16 and either Pob3 (yeast) or the related SSRP1 (higher eukaryotes). FACT is a general chromatin factor that acts to reorganise nucleosomes [, ]. In these proteins, the middle domain shows a double pleckstrin homology (PH) configuration and plays a role in DNA binding [, , ]. This entry represents the second PH domain, which is also found in Rtt106p, a histone chaperone involved in heterochromatin-mediated silencing []. |
