| First Author | García-Ferreras R | Year | 2023 |
| Journal | EMBO Rep | Volume | 24 |
| Issue | 7 | Pages | e56131 |
| PubMed ID | 37184882 | Mgi Jnum | J:337916 |
| Mgi Id | MGI:7508996 | Doi | 10.15252/embr.202256131 |
| Citation | Garcia-Ferreras R, et al. (2023) Bacteria-instructed B cells cross-prime naive CD8(+) T cells triggering effective cytotoxic responses. EMBO Rep 24(7):e56131 |
| abstractText | In addition to triggering humoral responses, conventional B cells have been described in vitro to cross-present exogenous antigens activating naive CD8(+) T cells. Nevertheless, the way B cells capture these exogenous antigens and the physiological roles of B cell-mediated cross-presentation remain poorly explored. Here, we show that B cells capture bacteria by trans-phagocytosis from previously infected dendritic cells (DC) when they are in close contact. Bacterial encounter "instructs" the B cells to acquire antigen cross-presentation abilities, in a process that involves autophagy. Bacteria-instructed B cells, henceforth referred to as BacB cells, rapidly degrade phagocytosed bacteria, process bacterial antigens and cross-prime naive CD8(+) T cells which differentiate into specific cytotoxic cells that efficiently control bacterial infections. Moreover, a proof-of-concept experiment shows that BacB cells that have captured bacteria expressing tumor antigens could be useful as novel cellular immunotherapies against cancer. |
