Primary Identifier | MGI:3767554 | Allele Type | Targeted |
Attribute String | Null/knockout | Gene | Tenm3 |
Transmission | Germline | Strain of Origin | (129X1/SvJ x 129S1/Sv)F1-Kitl<+> |
Is Recombinase | false | Is Wild Type | false |
molecularNote | Exon 4, encoding the trans-membrane domain was disrupted by the insertion of a neomycin cassette. Quantitative PCR analysis indicated that transcript expression was significantly reduced in homozygous mice. Western blot analysis confirmed the absence of protein in brain lysates from homozygous mice. |