| First Author | Silins G | Year | 1998 |
| Journal | Biochem Biophys Res Commun | Volume | 243 |
| Issue | 1 | Pages | 273-6 |
| PubMed ID | 9473517 | Mgi Jnum | J:45663 |
| Mgi Id | MGI:1195818 | Doi | 10.1006/bbrc.1997.8091 |
| Citation | Silins G, et al. (1998) Characterisation of a new human and murine member of the DnaJ family of proteins. Biochem Biophys Res Commun 243(1):273-6 |
| abstractText | We report the characterisation of a human gene, designated MCG18 (multiple endocrine neoplasia type 1 candidate gene 18), that encodes a new member of the DnaJ family of proteins. Database searches indicate that MCG18 also has the locus name HSPF2. MCG18 lies 250bp centromeric of the VRF/VEGFB gene on chromosome 11q13. The MCG18 cDNA is predicted to encode a 241 amino acid product that has partial homology to Escherichia coli dnaJ in that it contains the J domain. However, MCG18 has greatest similarity to a functionally undefined protein from Caenorhabditis elegans, both of which are predicted to have a membrane-spanning region adjacent to their J domains. The cDNA encoding the murine homolog (Mcg18) was also cloned and sequenced, and the encoded protein shares 81% similarity to MCG18. The coding region of MCG18 is interrupted by 4 introns and the mRNA is expressed as a 1.4kb message in all tissues examined, including those derived from the breast, ovary, bladder, lung and keratinocytes. |
