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Allele : Notch2<em1Rko> notch 2; endonuclease-mediated mutation 1, Raphael Kopan
Primary Identifier  MGI:6472982 Allele Type  Endonuclease-mediated
Attribute String  Not Specified Gene  Notch2
Is Recombinase  false Is Wild Type  false
molecularNote  Arginine codon 1934 wast targeted with a gRNA (GGCATCCAGATCGGTTACA) and a donor oligonucleotide using CRISPR/Cas9 technology. The resulting arginine to alanine mutation (p.R1934A) prevents dimerization of proteolytically created Notch intracellular domains (NICDs).
  • mutations:
  • Nucleotide substitutions
  • synonyms:
  • N2<R1934A>,
  • N2<RA>,
  • N2<RA>,
  • N2<R1934A>
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

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Trail: Allele




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