| First Author | First NJ | Year | 2023 |
| Journal | Cell Rep | Volume | 42 |
| Issue | 11 | Pages | 113294 |
| PubMed ID | 37883230 | Mgi Jnum | J:351823 |
| Mgi Id | MGI:7548217 | Doi | 10.1016/j.celrep.2023.113294 |
| Citation | First NJ, et al. (2023) Bordetella spp. block eosinophil recruitment to suppress the generation of early mucosal protection. Cell Rep 42(11):113294 |
| abstractText | Bordetella spp. are respiratory pathogens equipped with immune evasion mechanisms. We previously characterized a Bordetella bronchiseptica mutant (RB50DeltabtrS) that fails to suppress host responses, leading to rapid clearance and long-lasting immunity against reinfection. This work revealed eosinophils as an exclusive requirement for RB50DeltabtrS clearance. We also show that RB50DeltabtrS promotes eosinophil-mediated B/T cell recruitment and inducible bronchus-associated lymphoid tissue (iBALT) formation, with eosinophils being present throughout iBALT for Th17 and immunoglobulin A (IgA) responses. Finally, we provide evidence that XCL1 is critical for iBALT formation but not maintenance, proposing a novel role for eosinophils as facilitators of adaptive immunity against B. bronchiseptica. RB50DeltabtrS being incapable of suppressing eosinophil effector functions illuminates active, bacterial targeting of eosinophils to achieve successful persistence and reinfection. Overall, our discoveries contribute to understanding cellular mechanisms for use in future vaccines and therapies against Bordetella spp. and extension to other mucosal pathogens. |
