| First Author | Skokos D | Year | 2007 |
| Journal | J Exp Med | Volume | 204 |
| Issue | 7 | Pages | 1525-31 |
| PubMed ID | 17576775 | Mgi Jnum | J:125873 |
| Mgi Id | MGI:3760061 | Doi | 10.1084/jem.20062305 |
| Citation | Skokos D, et al. (2007) CD8- DCs induce IL-12-independent Th1 differentiation through Delta 4 Notch-like ligand in response to bacterial LPS. J Exp Med 204(7):1525-31 |
| abstractText | Toll-like receptor (TLR) ligation is believed to skew T cell responses toward T helper (Th)1 differentiation by inducing interleukin (IL)-12 secretion by CD8(+) dendritic cells (DCs). However, TLR-dependent Th1 responses occur in the absence of IL-12. To determine how DCs induce Th1 differentiation in the absence of IL-12, we examined the response of IL-12-deficient DCs to bacterial lipopolysaccharide (LPS). We find that LPS activates MyD88-dependent Delta 4 Notch-like ligand expression by CD8(-) DCs, and that these cells direct Th1 differentiation by an IL-12-independent and Notch-dependent mechanism in vitro and in vivo. Thus, activation of the two DC subsets by TLR4 leads to Th1 responses by two distinct MyD88-dependent pathways. |
