| First Author | Zhao B | Year | 2024 |
| Journal | Int J Mol Sci | Volume | 25 |
| Issue | 9 | PubMed ID | 38732181 |
| Mgi Jnum | J:348369 | Mgi Id | MGI:7640629 |
| Doi | 10.3390/ijms25094962 | Citation | Zhao B, et al. (2024) BAP31 Plays an Essential Role in Mouse B Cell Development via Regulation of BCR Signaling. Int J Mol Sci 25(9) |
| abstractText | B cell receptor-associated protein 31 (BAP31) is a transmembrane protein that is widely expressed and primarily located in the endoplasmic reticulum (ER). B cells play a crucial role in the immune system, and BAP31 significantly contributes to the functions of various immune cells. However, the specific role of BAP31 in B lymphocytes development remains unknown. In this study, we utilized a mouse model with BAP31 deleted from B cells to investigate its effects. Our findings reveal a block in early B cell development in the bone marrow and a significant decrease in the number of B cells in peripheral lymphoid organs taken from BAP31 B cell conditional knockout (BAP31-BCKO) mice. B cell receptor (BCR) signaling is crucial for the normal development and differentiation of B lymphocytes. BAP31, an endoplasmic reticulum membrane protein, directly regulates the BCR signaling pathway and was shown to be significantly positively correlated with B cell activation and proliferation. These findings establish BAP31 as a crucial regulator of early B cell development. |
